2023

Effects of activity levels on aortic calcification in hyperlipidemic mice as measured by microPETmicroCT

Hon A, Hsu JJ, Zambrano A, Xia Y, Lu M, Echeverri D, Kalanski S, Umar S, Demer LL, Tintut Y.

Atherosclerosis. 2023 Aug 2.

Potential mechanisms linking high-volume exercise with coronary artery calcification.

Zambrano A, Tintut Y, Demer LL, Hsu JJ.
Heart. 2023 Jan 26.

A Potential New Link Between Inflammation and Vascular Calcification

Cai X, Tintut Y, Demer LL.
J Am Heart Assoc. 2023 Jan 3.

Accelerated Cardiac Allograft Vasculopathy in an Orthotopic Heart Transplant Recipient with Prior COVID-19

Parikh NU, Dixit NM, Churchill AB, Oliveria-Kowaleski A, Lau RP, Fishbein GA, Hsu JJ
Am J Case Rep, 2023, March 1

2022

Early trends in cardiac allograft vasculopathy after implementation of the 2018 donor heart allocation policy in the United States

Tehrani DM, Kim JS, Hsu JJ, Nsair A, Khush KK, Fearon WF, Parikh RV
Am Heart J. 2022 Dec

Postural orthostatic tachycardia syndrome and orthostatic hypotension in post-acute sequelae of COVID-19 during pregnancy: a case report

Hanson J, Richley M, Hsu JJ, Lin J, Afshar Y
Eur Heart J Case Rep. 2022 Nov 30

Regulation of cardiovascular calcification by lipids and lipoproteins

Hsu JJ, Tintut Y, Demer LL
Curr Opin Lipidol. 2022 Oct 1.

Orthostatic and Exercise Intolerance Competitive Athletes with Long COVID

Rao P, Peritz DC, Systrom D, Lewine K, Cornwell WK 3^rd, Hsu JJ.
JACC Case Rep. 2022 Sept 7

The design of the Dashboard Activated Services and Telehealth for Heart Failure (DASH-HF) study: A pragmatic quality improvement randomized implementation trial for patients with heart failure with reduced ejection fraction

Verma A, Fonarow GC, Hsu JJ, Jackevicius CA, Mody FV, Amidi O, Goldberg S, Upparapalli D, Theodoropoulos K, Gregorio S, Chang DS, Bostrom K, Althouse A, Boback Ziaeian
Contemp Clin Trials. 2022 Sept

Microarchitectural Changes of Cardiovascular Calcification in Response to In Vivo Interventions Using Deep-Learning Segmentation and Computed Tomography Radiomics

Patel NR, Setya K, Pradhan S, Lu M, Demer LL, Tintut Y.
Arterioscler Thromb Vasc Biol. 2022 Aug

Hemodynamic effects of COVID-19 vaccination in hospitalized patients awaiting heart transplantation

Ohman R, DiVita M, Chonde M, Fraschilla S, Nsair A, Cruz D, Hsu JJ
Am Heart J Plus. 2022 June

2021

Biomolecules Orchestrating Cardiovascular Calcification.

Tintut Y, Honda HM, Demer LL.
Biomolecules. 2021 Oct 7.

Changes in microarchitecture of atherosclerotic calcification assessed by ¹⁸F-NaF PET and CT after a progressive exercise regimen in hyperlipidemic mice.
Hsu JJ, Fong F, Patel R, Qiao R, Lo K, Soundia A, Chang CC, Le V, Tseng CH, Demer LL, Tintut Y.
J Nucl Cardiol. 2021 Oct

Lipids and cardiovascular calcification: contributions to plaque vulnerability.
Hsu JJ, Tintut Y, Demer LL.
Curr Opin Lipidol. 2021 Oct 1

The Mechanobiology of Endothelial-to-Mesenchymal Transition in Cardiovascular Disease.

Islam S, Boström KI, Di Carlo D, Simmons CA, Tintut Y, Yao Y, Hsu JJ.
Front Physiol. 2021 Sep 9.

In Vivo Intravascular Pacing Using a Wireless Microscale Stimulator.

Abiri P, Duarte-Vogel S, Chou TC, Abiri A, Gudapati V, Yousefi A, Roustaei M, Chang CC, Cui Q, Hsu JJ, Bersohn M, Markovic D, Chen J, Tai YC, Hsiai TK.
Ann Biomed Eng. 2021 Sep

Potential impact of the steroid hormone, vitamin D, on the vasculature.
Tintut Y, Demer LL.
Am Heart J. 2021 Sep

A biomarker for vascular calcification: shedding light on an unfinished story?
Hsu JJ, Tintut Y, Demer LL.
Cardiovasc Res. 2021 Jul 7

Hearts of Stone: Calcific Aortic Stenosis and Antiresorptive Agents for Osteoporosis.
Demer LL, Tintut Y.
Circulation. 2021 Jun 22

Statin Effects on Vascular Calcification: Microarchitectural Changes in Aortic Calcium Deposits in Aged Hyperlipidemic Mice.
Xian JZ, Lu M, Fong F, Qiao R, Patel NR, Abeydeera D, Iriana S, Demer LL, Tintut Y.
Arterioscler Thromb Vasc Biol. 2021 Apr

Serotonin receptor type 2B activation augments TNF-α-induced matrix mineralization in murine valvular interstitial cells.
Fong F, Xian J, Demer LL, Tintut Y.
J Cell Biochem. 2021 Feb

2020

Asian-Americans and Pacific Islanders in COVID-19: Emerging Disparities Amid Discrimination.
Wang D, Gee GC, Bahiru E, Yang EH, Hsu JJ.
J Gen Intern Med. 2020 Dec.

Heart Failure With Mid-range Ejection Fraction.

Srivastava PK, Hsu JJ, Ziaeian B, Fonarow GC.
Curr Heart Fail Rep. 2020 Feb.

Wearable Sensors for COVID-19: A Call to Action to Harness Our Digital Infrastructure for Remote Patient Monitoring and Virtual Assessments.

Seshadri DR, Davies EV, Harlow ER, Hsu JJ, Knighton SC, Walker TA, Voos JE, Drummond CK.
Front Digit Health. 2020 Jun.

Heart transplantation in the early phase of the COVID-19 pandemic: A single-center case series.

Hsu JJ, Al-Saffar F, Ardehali R, Baas AS, Carlson M, Cruz D, Deng M, Fan A, Fraschilla S, Gaynor P, Kamath M, Kubak BM, Schaenman J, Stimpson E, Vucicevic D, Ardehali A, Nsair A.
Clin Transplant. 2020 Sep.

2019

Regulation of calcific vascular and valvular disease by nuclear receptors.

Sallam T, Tintut Y, Demer LL.
Curr Opin Lipidol. 2019 Oct

Interactive and Multifactorial Mechanisms of Calcific Vascular and Valvular Disease.

Demer LL, Tintut Y.
Trends Endocrinol Metab. 2019 Sep

Contractile and hemodynamic forces coordinate Notch1b-mediated outflow tract valve formation.

Hsu JJ, Vedula V, Baek KI, Chen C, Chen J, Chou MI, Lam J, Subhedar S, Wang J, Ding Y, Chang CC, Lee J, Demer LL, Tintut Y, Marsden AL, Hsiai TK.
JCI Insight. 2019 Apr 11

2018

Lipoproteins in Cardiovascular Calcification: Potential Targets and Challenges.

Tintut Y, Hsu JJ, Demer LL.
Front Cardiovasc Med. 2018 Nov 23

Multiscale light-sheet for rapid imaging of cardiopulmonary system.

Ding Y, Ma J, Langenbacher AD, Baek KI, Lee J, Chang CC, Hsu JJ, Kulkarni RP, Belperio J, Shi W, Ranjbarvaziri S, Ardehali R, Tintut Y, Demer LL, Chen JN, Fei P, Packard RRS, Hsiai TK.
JCI Insight. 2018 Aug 23

Steroid Hormone Vitamin D: Implications for Cardiovascular Disease.

Demer LL, Hsu JJ, Tintut Y.
Circ Res. 2018 May 25

Effects of teriparatide on morphology of aortic calcification in aged hyperlipidemic mice.

Hsu JJ, Lu J, Umar S, Lee JT, Kulkarni RP, Ding Y, Chang CC, Hsiai TK, Hokugo A, Gkouveris I, Tetradis S, Nishimura I, Demer LL, Tintut Y.
Am J Physiol Heart Circ Physiol. 2018

2017

Rigor and Reproducibility in Analysis of Vascular Calcification.

Demer LL, Tintut Y, Nguyen KL, Hsiai T, Lee JT.
Circ Res. 2017 Apr 14

Reply: Evolutionary approach sheds light on the significance of vascular calcification.

Demer LL, Tintut Y.
Trends Cardiovasc Med. 2017 Jan

2016

Activating transcription factor-4 promotes mineralization in vascular smooth muscle cells.

Masuda M, Miyazaki-Anzai S, Keenan AL, Shiozaki Y, Okamura K, Chick WS, Williams K, Zhao X, Rahman SM, Tintut Y, Adams CM, Miyazaki M.
JCI Insight. 2016 Nov 3

Cell-matrix mechanics and pattern formation in inflammatory cardiovascular calcification.

Hsu JJ, Lim J, Tintut Y, Demer LL.
Heart. 2016 Nov 1

Inflammation Drives Retraction, Stiffening, and Nodule Formation via Cytoskeletal Machinery in a Three-Dimensional Culture Model of Aortic Stenosis.

Lim J, Ehsanipour A, Hsu JJ, Lu J, Pedego T, Wu A, Walthers CM, Demer LL, Seidlits SK, Tintut Y.
Am J Pathol. 2016 Sep

COMP-lex Mechanics: Matricrine Signaling.

Tintut Y, Demer LL.
Circ Res. 2016 Jul 8

2015

Protective Role of Smad6 in Inflammation-Induced Valvular Cell Calcification.
Lim JJ, Li X, Lu J, Pedego TM, Demer L, Tintut Y.
J Cell Biochem. 2015 Apr 10.

Exosomes: nanosized cellular messages.
Tintut Y, Demer LL.
Circ Res. 2015 Apr 10;116(8):1281-3.

The leading edge of vascular calcification.
Demer LL, Tintut Y.
Trends Cardiovasc Med. 2015 May;25(4):275-7.

2014

Hyperlipidemia affects multiscale structure and strength of murine femur.
Ascenzi MG, Lutz A, Du X, Klimecky L, Kawas N, Hourany T, Jahng J, Chin J, Tintut Y, Nackenhors U, Keyak J.
J Biomech. 2014 Jul 18;47(10):2436-43.

Inflammatory, metabolic, and genetic mechanisms of vascular calcification.
Demer LL, Tintut Y.
Arterioscler Thromb Vasc Biol. 2014 Apr;34(4):715-23.

FGF23 protein expression in coronary arteries is associated with impaired kidney function.
Van Venrooij NA, Pereira RC, Tintut Y, Fishbein MC, Tumber N, Demer LL, Salusky IB, Wesseling-Perry K.
Nephrol Dial Transplant. 2014 Jan 23.

Inflammatory, metabolic, and genetic mechanisms of vascular calcification.
Demer LL, Tintut Y.
Arterioscler Thromb Vasc Biol. 2014 Apr;34(4):715-23.

Effects of bioactive lipids and lipoproteins on bone.
Tintut Y, Demer LL.
Trends Endocrinol Metab. 2014 Feb;25(2):53-9.

Roles of parathyroid hormone (PTH) receptor and reactive oxygen species in hyperlipidemia-induced PTH resistance in preosteoblasts.
Li X, Garcia J, Lu J, Iriana S, Kalajzic I, Rowe D, Demer LL, Tintut Y.
J Cell Biochem. 2014 Jan;115(1):179-88.

2013

The Effects of Hyperlipidemia on Implant Osseointegration in the Mouse Femur.
Keuroghlian A, Barroso AD, Kirikian G, Bezouglaia O, Tintut Y, Tetradis S, Pirih FQ, Aghaloo T.
J Oral Implantol. 2013 Dec 2.

Introduction to the Compendium on calcific aortic valve disease.
Heistad DD, Shanahan C, Demer LL.
Circ Res. 2013 Jul 5;113(2):176-8.

Role of paraoxonase-1 in bone anabolic effects of parathyroid hormone in hyperlipidemic mice.
Lu J, Cheng H, Atti E, Shih DM, Demer LL, Tintut Y.
Biochem Biophys Res Commun. 2013 Feb 1;431(1):19-24.

Regulatory circuits controlling vascular cell calcification.
Sallam T, Cheng H, Demer LL, Tintut Y.
Cell Mol Life Sci. 2013 Sep;70(17):3187-97.

2012

Atmospheric ultrafine particles promote vascular calcification via the NF-κB signaling pathway.
Li R, Mittelstein D, Kam W, Pakbin P, Du Y, Tintut Y, Navab M, Sioutas C, Hsiai T.
Am J Physiol Cell Physiol. 2013 Feb 15;304(4):C362-9.

Preferred mitotic orientation in pattern formation by vascular mesenchymal cells.
Wong MN, Nguyen TP, Chen TH, Hsu JJ, Zeng X, Saw A, Demer EM, Zhao X, Tintut Y, Demer LL.
Am J Physiol Heart Circ Physiol. 2012 Dec 15;303(12):H1411-7.

Enhanced mineralization potential of vascular cells from SM22α-Rankl (tg) mice.
Morony S, Sage AP, Corbin T, Lu J, Tintut Y, Demer LL.
Calcif Tissue Int. 2012 Dec;91(6):379-86.

Directing tissue morphogenesis via self-assembly of vascular mesenchymal cells.
Chen TH, Zhu X, Pan L, Zeng X, Garfinkel A, Tintut Y, Demer LL, Zhao X, Ho CM.
Biomaterials. 2012 Dec;33(35):9019-26.

Focal high cell density generates a gradient of patterns in self-organizing vascular mesenchymal cells.
Cheng H, Reddy A, Sage A, Lu J, Garfinkel A, Tintut Y, Demer LL.
J Vasc Res. 2012;49(5):441-6.

Patterns of periodic holes created by increased cell motility.
Chen TH, Guo C, Zhao X, Yao Y, Boström KI, Wong MN, Tintut Y, Demer LL, Ho CM, Garfinkel A.
Interface Focus. 2012 Aug 6;2(4):457-64.

Left-right symmetry breaking in tissue morphogenesis via cytoskeletal mechanics.
Chen TH, Hsu JJ, Zhao X, Guo C, Wong MN, Huang Y, Li Z, Garfinkel A, Ho CM, Tintut Y, Demer LL.
Circ Res. 2012 Feb 17;110(4):551-9.

A dynamic model of calcific nodule destabilization in response to monocyte- and oxidized lipid-induced matrix metalloproteinases.
Li R, Mittelstein D, Lee J, Fang K, Majumdar R, Tintut Y, Demer LL, Hsiai TK.
Am J Physiol Cell Physiol. 2012 Feb 15;302(4):C658-65.

Adverse effects of hyperlipidemia on bone regeneration and strength.
Pirih F, Lu J, Ye F, Bezouglaia O, Atti E, Ascenzi MG, Tetradis S, Demer L, Aghaloo T, Tintut Y.
J Bone Miner Res. 2012 Feb;27(2):309-18.